![]() But we will cover the full glide callouses metabolic pathway later in our course. And so again, we're not showing you the full light, callous iss uh, metabolic pathway here. And of course, one of the final products of glide Collis iss is the net generation of ATP. Collis is process or metabolic pathway and over here on the far left notice, we're starting with a glucose molecule. And so notice down below in our image, we're showing you a little snippet of the glide. And so recall from your previous biology courses that glide colle assists is just a process in cellular respiration that breaks down glucose in order to generate energy in the form of ATP. So now that we've covered the basics of negative feedback or feedback inhibition in this video, we're going to cover an example of feedback regulation in glide colle assists. So later, in our course, we're going to talk about many different examples of negative feedback, and in our next lesson, video will specifically talk about one particular example. And so it turns out again that negative feed bank, um, inhibition is an efficient and a common means for biochemical regulations. And so, by coming back in inhibiting enzyme number one, uh, product F can, uh, influence the decrease or the lowering of it's a concentration. Molecules such as product F here are able to regulate its own production. And so clearly here we're talking about negative feedback inhibition, and you can see how, really, through negative feedback inhibition. And that's going to allow the metabolic pathway to proceed once again. And so when the final concentration of the product F over here is returned back to normal or lower levels, then the feedback inhibition that is caused by product F here is essentially going to stop. And so if F comes all the way back to inhibit enzyme number one, then that's going to prevent the conversion from A to B, and ultimately, that's going to lead to the decrease of the concentration of product F. And we know that it's inhibiting because again, we have a minus sign here that represents inhibition. Af And, uh, if the concentration of F happens to get way too high, then f can actually come back and inhibit the Alice Derek Enzyme number one here. And so notice here that we have a final product. But here we do have one enzyme that is displaying Alistair kinetics. And so, over here we're showing you an example of a metabolic pathway, and so you can see that we have all of these reactions here and notice that most of these reactions are being catalyzed by Michalis mention enzymes. And so, over here, what we have is a red light to show you that really negative feedback acts like a red light and slows down these metabolic pathways. In our example notice, we're saying that negative feedback inhibition really acts like the red light to inhibit metabolic pathways. ![]() And of course, that means that it's not going to bind to the enzymes active site and so down below. And so these negative feedback inhibitors are going to bind to an Alice, Terek and Allah host Eric site on the A list Eric Enzyme. And so as we'll see down below, in our example uh, negative feedback inhibitors really do, uh, inhibitors really do act as inhibitors and recall that inhibitors are commonly represented with a negative symbol. ![]() And so ultimately this is going to slow down, uh, the entire metabolic pathway, and that is going to begin to decrease the final concentration of that product that acted to inhibit the reaction. And so negative feedback inhibition is when the final product or just ah later product in a metabolic pathway can come back and inhibit an earlier step in the same exact metabolic pathway that led to that products production. And so as we'll see moving forward, negative feedback is really just a way for molecules, such as a product to regulate the production of its own activity. Now, really, the purpose of negative feedback is to prevent the over production as well as the wasteful production of a product. Inhibition is an efficient and a very common means for biochemical regulation, and so cells use negative feedback all the time to regulate their reactions. And so negative feedback is also sometimes referred to as just feedback inhibition. In this video, we're going to introduce yet another way that cells can regulate their biochemical reactions, and that is through negative feedback. ![]()
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